Our studies indicate that long-life growth hormone deficiency leads to deficient and abnormal distribution of bone mineralization, a more pronounced deficit of BMD at the cortical bone, mainly expressed in the shafts of the long bones of the legs and arms, and moderately reduced BMD at the trabecular bone.
Bone scans displaying low diphosphonates uptake in the shafts of the long bones point to greatly suppressed skeletal metabolism of the cortical bone in the patients with CO hypopituitarism never treated with GH.
Kosowicz J, El Ali Z, Ziemnicka K, Sowinski J Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.
2007 Jul-Sep 10(3):332-9 Language: eng Country: United States Department of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
In the present study we examined the effect of pulsatile administration of two dosages of GHRH (4×25 or 4x50mug intravenously, respectively) on sleep electroencephalogram (EEG) and nocturnal hormone secretion in healthy young women according to a randomized schedule.
To rule out the influence of gonadal hormone activity, the study was adapted to the phase of the menstrual cycle and was performed at 4-6th day of menstrual cycle.
In the presence of two or more additional pituitary hormone deficiencies, an IGF-I level BONE MINERAL DENSITY Abnormalities in bone mineral density distribution and bone scintigraphy in patients with childhood onset hypopituitarism.Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women. Department of Psychiatry, Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.Mathias S, Held K, Ising M, Weikel JC, Yassouridis A, Steiger A. In young male subjects peripherally administered growth hormone-releasing hormone (GHRH) enhances GH and slow wave sleep (SWS) and blunts cortisol.In contrast, in a sample of females 19-76-year old, GHRH impairs sleep and enhances adrenocorticotropic hormone (ACTH) and cortisol.In the latter study, the days of investigation were not adapted to the menstrual cycle and premenopausal and postmenopausal women as well were included.